The advent of anti-vascular endothelial growth has massively resulted in reducing the vision loss caused by neovascular age-related macular degeneration (n-AMD).
The response of the anti-VEGF therapy relies on various factors such as the patient’s lesion characteristics, age, lesion duration, baseline visual acuity, and various genotype risk alleles. In addition, individuals affected with n-AMD result in decreasing morphology or acuity, even after therapy, or it may need frequent re-treatment.
Vascular endothelial growth factor involves numerous pathological processes. It is widely utilized in the RD of various illness therapies.
The anti-VEGF therapeutics industry has generated $12,178.0 million revenue in 2021, and it is projected to generate $13,812.6 million revenue, advancing at a rate of 1.4% from 2021 to 2030. It is widely influenced by FDA approvals for products in the pipeline, including RD activities in the field.
The overexpression of VEGF contributes to the development of diseases. For instance, solid tumors need an increased blood supply for continuous growth beyond a certain size and tumor, as VEGF stimulates new blood vessel formation, usually known as angiogenesis.
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Cancers reflecting VEGF grow and expands to other organs and regions of the body. The protein expression is usually associated with the poor survival rates of tumors that reflect VEGF, most specifically in patients with breast cancers.
VEGF results in the development of diabetic retinopathy, and age-related macular degeneration in wet form. Therefore, anti-VEGF is crucial for the treatment of such conditions.
Moreover, the rising prevalence of ophthalmic diseases such as AMD, macular edoema, DR, and retinal vein occlusion, due to the increasing elderly population propels the risk of developing various diseases. It leads to increased demand for anti-VEGF therapeutics to treat such conditions.
On average, people aged 50 years or more are more likely to get blind due to rising incidences of AMD. More than 6.22 million people are more likely to be affected by moderate-to-sever vision impairment. Furthermore, the rising adoption of anti-VEGF medications has resulted in reduced incidences of AMD blindness by 20% from 2000 to 2020.
The companies operating in the industry are participating in RD and product launches relevant to anti-VEGF therapeutics.
Kodiak Sciences developed an anti-VEGF antibody biopolymer conjugate for individuals with DME and enrolled in GLEAM and GLIMMER phase-3 clinical trials successfully in February 2022.
Innovent Biologics Inc. also made phase-lb clinical trial data of IBI302 available to the public. It is the foremost ophthalmic recombinant human anti-VEGF protein and anti-complement bi-specific fusion targeted at neovascular AMD.
The major companies operating in the industry are; Biogen, F.Hoffmann-La Roche Ltd., Bausch Health Companies Inc., Pfizer Inc., Amgen Inc., Bayer AG, Novartis AG, Regeneron Pharmaceuticals Inc., and CoherusBioSciences.
The rising prevalence of ophthalmic diseases such as macular edoema, retinal vein occlusion, and AMD with the increasing elderly population boosts the demand for anti-VEGF therapeutics.
